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Abstract #74684 Published in IGR 19-1
Difference in patterns of retinal ganglion cell damage between primary open-angle glaucoma and non-arteritic anterior ischaemic optic neuropathy
Lee YH; Kim KN; Heo DW; Kang TS; Lee SB; Kim CSPLoS ONE 2017; 12: e0187093
PURPOSE: To compare the patterns of retinal ganglion cell damage between primary open-angle glaucoma (POAG) and non-arteritic anterior ischaemic optic neuropathy (NAION). METHODS: In total, 35 eyes with unilateral NAION, and 70 age- and average peripapillary retinal nerve fibre layer (RNFL) thickness-matched eyes with POAG, were enrolled as disease groups; 35 unaffected fellow eyes of the NAION, and 70 age- and refractive error-matched normal subjects for the POAG, were enrolled as their control groups, respectively. The peripapillary RNFL thickness and macular ganglion cell plus inner plexiform layer (GCIPL) thickness were compared between the disease groups and their controls, and between the two disease groups. RESULTS: Mean RNFL thicknesses at the 1 and 2 o'clock (superonasal) positions were thinner in NAION than in POAG (both p < 0.05). Mean RNFL thickness at 7 o'clock (inferotemporal) was thinner in POAG than in NAION (p = 0.001). Although there was no significant difference between NAION and POAG in average GCIPL thickness, all of the sectoral GCIPL thicknesses were thinner in NAION (all p < 0.05), except in the inferior and inferotemporal sectors. The ranges of the clock-hour RNFL with damage greater than the average RNFL thickness reduction, versus fellow eyes and control eyes, were 7 hours in NAION and 4 hours in POAG. CONCLUSIONS: The more damaged clock-hour RNFL regions differed between NAION (1 and 2 o'clock) and POAG (7 o'clock). Most sectoral GCIPL thicknesses were thinner in NAION than in POAG.
Department of Ophthalmology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Korea.
Full articleClassification:
10 Differential diagnosis e.g. anterior and posterior ischemic optic neuropathy
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
