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Abstract #75404 Published in IGR 19-2
Ocular Hypertension/Glaucoma in Minipigs: Episcleral Veins Cauterization and Microbead Occlusion Methods
Vecino E; Urcola H; Bayon A; Sharma SCMethods in molecular biology (Clifton, N.J.) 2018; 1695: 41-48
Two methods to induce elevation of the intraocular pressure (experimental glaucoma) are described in the present chapter. The first method is based on increasing the post-trabecular resistance to aqueous outflow by cauterizing the episcleral veins (EVC). This method allows the observation of ultrastructural changes in the trabecular meshwork (TM) without interfering with any structure within the eye such as TM, ciliary body, and/or the Retina. The second method is the multiple injection of microbeads into the anterior chamber, as a pre and intra-trabecular method that induce secondary effects on the TM cells. Both methods lead to an increase in IOP.
Experimental Ophathalmo-Biology Group, Department Cell Biology and Histology, University of the Basque Country, Barrio Sarriena s/n, Leioa, 48940, Vizcaya, Spain. elena.vecino@ehu.es.
Full articleClassification:
5.3 Other (Part of: 5 Experimental glaucoma; animal models)
