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Abstract #75446 Published in IGR 19-2
The Association of Single-Nucleotide Polymorphisms in the MMP-9 Gene with Normal Tension Glaucoma and Primary Open-Angle Glaucoma
Suh W; Won HH; Kee CCurrent Eye Research 2018; 43: 534-538
PURPOSE: To evaluate the association of matrix metalloproteinases (MMP)-9 gene polymorphisms with normal tension glaucoma (NTG) and primary open-angle glaucoma (POAG) in the South Korean population. MATERIALS AND METHODS: A total of 700 South Korean subjects were recruited: 146 patients with NTG, 174 patients with POAG, and 380 healthy adults. Five single-nucleotide polymorphisms (SNPs; rs3918429, rs2274755, rs3787268, rs3918261, and rs3918270) of MMP-9 were analyzed in all subjects. The association with each disease was tested using an allelic χ test and p values were corrected by permutation tests with 100 000 permutations. RESULTS: Among the five SNPs, rs2274755 showed a significant association with NTG (p = 0.021). The T allele of rs2274755 had an allelic odds ratio of 1.67 (95% confidence interval, 1.12-2.50). The association remained significant after correction using permutation tests (p = 0.039). It was also significant in an association analysis for genotype frequency (p = 0.011). The SNP was predicted to be found within a splicing site and a conserved region. No SNPs analyzed were significantly associated with POAG (p > 0.05). CONCLUSIONS: The rs2274755 SNP in the MMP-9 gene was significantly associated with NTG. This supports a possible role of the MMP-9 gene in NTG pathogenesis.
a Department of Ophthalmology , Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine , Hwaseong , Gyeonggido , Korea.
Full articleClassification:
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
