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Abstract #75489 Published in IGR 19-2
Central Visual Field Damage and Parapapillary Choroidal Microvasculature Dropout in Primary Open-Angle Glaucoma
Lee EJ; Kim TW; Kim JAOphthalmology 2018; 125: 588-596
PURPOSE: To determine whether microvasculature dropout (MvD) in the parapapillary choroid is related to the presence of central visual field defects in primary open-angle glaucoma (POAG). DESIGN: Cross-sectional observational study. PARTICIPANTS: Thirty-two POAG patients with an initial parafoveal scotoma (IPFS) within a 10° radius in 1 hemifield and 42 POAG patients with an initial nasal step (INS) within the nasal periphery outside 10° of fixation in 1 hemifield. METHODS: The peripapillary choroidal microvasculature was evaluated on en face images obtained using swept-source OCT angiography. Microvasculature dropout was defined as a focal sectoral capillary dropout with no visible microvascular network identified in the choroidal layer. Factors associated with IPFS, compared with INS, were assessed using logistic regression analyses. MAIN OUTCOME MEASURES: Factors associated with IPFS rather than INS. RESULTS: Microvasculature dropout was observed in 25 of 32 eyes (78.1%) in the IPFS group, but in only 1 of 42 eyes (2.4%) in the INS group (P < 0.001). In logistic regression analyses, only MvD was a significant factor influencing the presence of IPFS. Systemic risk factors such as cold extremities (P = 0.026), migraine (P = 0.044), lower mean arterial pressure (P = 0.037), and lower ocular perfusion pressure (P = 0.024) were associated significantly with the presence of MvD. CONCLUSIONS: The presence of MvD in the parapapillary choroid was a strong predictor for IPFS.
Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, South Korea.
Full articleClassification:
2.12 Choroid, peripapillary choroid, peripapillary atrophy (Part of: 2 Anatomical structures in glaucoma)
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
