advertisement
Abstract #76778 Published in IGR 19-3
Ocular microcirculation measurement with laser speckle flowgraphy and optical coherence tomography angiography in glaucoma
Kiyota N; Kunikata H; Shiga Y; Omodaka K; Nakazawa TActa Ophthalmologica 2018; 96: e485-e492
PURPOSE: To compare glaucoma severity with ocular microcirculation, measured with either laser speckle flowgraphy (LSFG) or optical coherence tomography angiography (OCTA). METHODS: We retrospectively studied 82 eyes of 82 open-angle glaucoma (OAG) patients who underwent same-day LSFG and OCTA examinations, with 20 eyes of 20 healthy subjects as controls. In OCTA images, vessel density (VD) (%) was calculated in concentric regions (regions 1, 2 and 3: R1, R2 and R3, respectively) defined by 1.6-, 3.2- and 3.6-mm-diameter circles around the optic nerve head (ONH). In R3, the large vessels were automatically masked to calculate pure capillary density (auto R3 VD). LSFG-measured mean blur rate (MBR) was examined in the overall ONH (MA), vessel-area ONH (MV) and tissue-area ONH (MT). RESULTS: Auto R3 VD had high reproducibility (coefficient of variation: 1.65-3.88%) and accurately reflected manual R3 VD [mean bias: -0.0087% (auto R3 VD - manual R3 VD)]. MA and MT decreased significantly with OAG severity, especially in the early OAG stages (control vs. mild: p = 0.003 and p < 0.001, respectively). R1 VD did not change with severity. R2 and auto R3 VD decreased significantly with OAG severity, especially in the severe stages (R2, mild vs. severe: p = 0.008; auto R3 VD, mild vs. severe: p < 0.001, moderate vs. severe: p = 0.028). CONCLUSION: Optical coherence tomography angiography-derived auto R3 VD is novel, reproducible and accurately reflects manual measurements. It is useful for differentiating moderate and advanced glaucoma, while LSFG-derived MT is useful for identifying early glaucoma.
Department of Ophthalmology, Tohoku University Graduate School of Medicine, Sendai, Japan.
Full articleClassification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)