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Abstract #76852 Published in IGR 19-3
Association Between the Deep-layer Microvasculature Dropout and the Visual Field Damage in Glaucoma
Suh MH; Park JW; Kim HRJournal of Glaucoma 2018; 27: 543-551
PURPOSE: To compare the visual field (VF) sensitivity according to the presence of parapapillary deep-layer microvasculature dropout (MvD_P) and focal lamina cribrosa (LC) defect. MATERIALS AND METHODS: Among 158 open-angle glaucoma patients, 4 groups were formed according to the presence of MvD_P and focal LC defect determined by optical coherence tomography (OCT) angiography and by enhanced depth imaging spectral-domain OCT, respectively: (1) eyes without either focal LC defect or MvD_P (group 1); (2) eyes with focal LC defect but no MvD_P (group 2); (3) eyes without focal LC defect but with MvD_P (group 3); (4) eyes with both focal LC defect and MvD_P (group 4). VF sensitivity and retinal nerve fiber layer (RNFL) thickness were compared among the 4 groups for global area and 6 sectors. RESULTS: Both RNFL thickness and VF sensitivity differed among the 4 groups in all areas other than the nasal and superonasal sectors for RNFL thickness. On post hoc analysis, eyes with MvD_P (groups 3 and 4) had significantly worse VF sensitivity than group 2 [P<0.05, 1-way analysis of variance (ANOVA)] in all areas except the superotemporal and temporal sectors, whereas the RNFL thicknesses did not differ (P>0.05, 1-way ANOVA) in any areas except the superotemporal sector. CONCLUSIONS: Eyes with MvD_P had worse VF sensitivity than those without MvD_P, and VF difference was more distinguished than differences of axonal loss and focal LC change. Further studies on the temporal relationship between the MvD_P and glaucomatous VF progression are warranted.
Department of Ophthalmology, Haeundae Paik Hospital, Inje University College of Medicine, Busan, South Korea.
Full articleClassification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.12 Choroid, peripapillary choroid, peripapillary atrophy (Part of: 2 Anatomical structures in glaucoma)
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
