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Abstract #77198 Published in IGR 19-3
Serum Bile Acids in Patients with Primary Open Angle Glaucoma
Jacob MM; Pai H V; Gnanaharan J; Kamath SJournal of Glaucoma 2018; 27: 687-690
PURPOSE: To measure the serum bile acids (SBA) in patients with Primary open angle glaucoma (POAG) and to compare with non-glaucomatous controls. PATIENTS AND METHODS: A hospital based case control study of 90 patients above the age of 40 years was conducted. Patients with Primary open angle glaucoma formed the study group and individuals without glaucoma in the same age group formed the control group. Serum bile acid estimation was done using ELISA kit enzymatic assay technique and the median value was compared between the two groups. RESULTS: The median of SBA level was found to be more in POAG patients when compared with the control group. The difference was statistically significant (P<0.001). Median SBA level was not affected by the age or gender of the participants in the study. CONCLUSION: 'Bile acids' may have a role in the oxidative stress and apoptosis involved in the pathophysiology of 'Primary open angle glaucoma' (POAG).
Department of Ophthalmology, Kasturba Hospital, Manipal Academy of Higher Education, Manipal, India.
Full articleClassification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
3.7 Biochemistry (Part of: 3 Laboratory methods)
