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Abstract #77930 Published in IGR 19-4
Neuroprotection in glaucoma: recent advances and clinical translation
Guymer C; Wood JP; Chidlow G; Casson RJClinical and Experimental Ophthalmology 2018; 0:
Intraocular pressure (IOP) reduction is currently the only evidence-based treatment strategy for glaucoma. However, IOP control in some individuals is challenging. Despite optimal treatment, a significant proportion of individuals will progress, with loss of visual field, loss of driving vision and impaired quality of life. A new modality that could augment current treatment and reduce the rate of neurodegeneration to preserve vision throughout life would be a major breakthrough. A vast number of studies have reported effective neuroprotection in animal models of glaucoma; however, translation to the clinic remains a major hurdle. Herein, we explore the therapeutic advancements in non-IOP-dependent neuroprotection research based upon potential pathogenic mechanisms and propose strategies to improve the clinical translation of neuroprotective research in glaucoma.
Ophthalmic Research Laboratory, South Australian Institute of Ophthalmology, University of Adelaide, Adelaide, South Australia, Australia.
Full articleClassification:
11.8 Neuroprotection (Part of: 11 Medical treatment)
