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Abstract #77962 Published in IGR 19-4
Age-Related Changes in Human Schlemm's Canal: An Optical Coherence Tomography-Based Study
Zhao Y; Chen J; Yu X; Xu J; Sun X; Hong JFrontiers in physiology 2018; 9: 630
To investigate age-related changes in human Schlemm's canal (SC) using spectral-domain optical coherence tomography (SD-OCT). A total of 125 normal eyes were imaged using SD-OCT nasally and temporally. The age-related variations of SC sagittal diameter and cross-sectional area (CSA) from four age groups [A (16-20 years), B (21-40 years), C (41-60 years), and D (61-80 years)] were analyzed with Spearman correlation. The positive detection rates of SC showed a significantly downward trend with age. The mean CSA was 13,296 ± 1,897 μm nasally and 14,552 ± 2,589 μm temporally. The mean CSA was significantly larger in the temporal than in the nasal region ( < 0.05). Nasal CSA values varied among the four age groups ( = 0.004). Our study found for the first time that SC exhibits a morphological variant with age in healthy humans. Clinicians may need to consider this phenomenon when performing examinations targeting SC for glaucoma patients.
Department of Ophthalmology and Visual Science, Shanghai Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China.
Full articleClassification:
2.5.2 Schlemms canal (Part of: 2 Anatomical structures in glaucoma > 2.5 Meshwork)
6.9.2.1 Anterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)