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Abstract #78219 Published in IGR 19-4
Association between Nonalcoholic Fatty Liver Disease and Intraocular Pressure in Korean Adults
Kwon YJ; Kim JH; Jung DHJournal of Glaucoma 2018; 0:
PURPOSE: Elevated intraocular pressure is an important modifiable risk factor predicting glaucoma progression. Recent studies have demonstrated that metabolic risk factors influence intraocular pressure. Non-alcoholic fatty liver (NAFLD) is an emerging chronic liver disease that is closely associated with metabolic syndrome, obesity and type 2 diabetes. Therefore, we investigated the relationship between NAFLD and intraocular pressure in Korean adults. PATIENTS AND METHODS: This retrospective cross-sectional study analyzed a total of 7681 participants who visited a local health promotion center. NAFLD was defined via ultrasonography and patients were classified into three groups based on severity: normal, mild, and moderate to severe. We conducted multiple logistic regression analysis to examine the relationship between NAFLD and high intraocular pressure. We additionally performed multiple linear regression analysis to investigate the independent association between NAFLD and mean intraocular pressure. RESULTS: Mean IOP levels significantly and linearly increased with increasing NAFLD grades. Compared to normal, the odds ratio and 95% confidence intervals for high intraocular pressure were 1.09 (0.96-1.24) for mild NAFLD and 1.28 (1.12-1.48) for moderate to severe NAFLD after adjusting for confounding factors. NAFLD severity was noticed as an independent factor associated with mean IOP levels using stepwise and enter methods for multiple linear regression analyses. CONCLUSION: NAFLD severity was associated with high intraocular pressure (>15▒mm Hg) in Korean adults in a dose-dependent manner.
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Classification:
6.1.3 Factors affecting IOP (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
