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Abstract #78902 Published in IGR 20-1
Stamenkovic M; Stamenkovic M; Lukic V; Suvakov S; Simic T; Sencanic I; Pljesa-Ercegovac M; Jaksic V; Babovic S; Matic M; Radosavljevic A; Savic-Radojevic A; Djukic TInternational Journal of Ophthalmology 2018; 11: 1514-1520
AIM: To evaluate glutathione transferase theta 1 and mu 1 ( and ) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of and polymorphisms. The differences between two groups were tested by the -test or test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of genotype did not contribute independently towards the risk of POAG. However, individuals with genotype were at almost two-fold increased risk to develop glaucoma (=0.044) which increased up to 4.36 when combined with carriers (=0.024). When glutathione transferase () genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of genotype had significantly increased risk of POAG development in comparison with genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, =0.003; OR=10.02, <0.001; OR=4.53, =0.002). CONCLUSION: The results obtained indicate that both and genotypes are associated with increased POAG risk among smokers, suggesting potential gene-environment interaction in glaucoma development.
Full article
Classification:
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
3.5 Molecular biology incl. SiRNA (Part of: 3 Laboratory methods)
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
