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Abstract #79115 Published in IGR 20-1
Ascorbic acid metabolites are involved in intraocular pressure control in the general population
Hysi PG; Khawaja AP; Menni C; Tamraz B; Wareham N; Khaw KT; Foster PJ; Benet LZ; Spector TD; Hammond CJRedox biology 2019; 20: 349-353
Elevated intraocular pressure (IOP) is an important risk factor for glaucoma. Mechanisms involved in its homeostasis are not well understood, but associations between metabolic factors and IOP have been reported. To investigate the relationship between levels of circulating metabolites and IOP, we performed a metabolome-wide association using a machine learning algorithm, and then employing Mendelian Randomization models to further explore the strength and directionality of effect of the metabolites on IOP. We show that O-methylascorbate, a circulating Vitamin C metabolite, has a significant IOP-lowering effect, consistent with previous knowledge of the anti-hypertensive and anti-oxidative role of ascorbate compounds. These results enhance understanding of IOP control and may potentially benefit future IOP treatment and reduce vision loss from glaucoma.
Section of Academic Ophthalmology, Faculty of Life Sciences and Medicine, Kings' College London, UK; King's College London Department of Twin Research and Genetic Epidemiology, London, UK. Electronic address: pirro.hysi@kcl.ac.uk.
Full articleClassification:
6.1.3 Factors affecting IOP (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
3.7 Biochemistry (Part of: 3 Laboratory methods)