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Abstract #79151 Published in IGR 20-1
Association of gene common sequence variants in Jordanian patients with exfoliation syndrome and exfoliative glaucoma
Shihadeh W; Khabour O; Khalil MB; Al-Dabbagh A; Al-Hashimi MInternational Journal of Ophthalmology 2018; 11: 1583-1587
AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the gene with exfoliation syndrome/glaucoma (XFS/XFG) among Jordanians. METHODS: Sixty-one patients with XFS/XFG and 59 healthy control individuals were recruited in the study. Patients were diagnosed with XFS/XFG using standard clinical examination techniques. The exonic rs1048661 SNP and the intronic rs2165241 SNP in gene were genotyped using sequencing technique. Allele and genotype frequencies were compared between cases and controls using Chi-square analysis. RESULTS: The G allele of the rs1048661 SNP and the T allele of the rs2165241 SNP were common in the sample with frequencies of 86.4% and 81.4%, respectively. In addition, there were no significant differences in the genotypic and allelic distributions between patients and controls for rs1048661 SNP (=0.770, OR=1.21, 95%CI: 0.56-2.60) and for rs2165241 SNP (=0.605, OR=1.12, 95%CI: 0.59-2.09). In addition, no significant associations were found between haplotypes of the examined SNPs and XFS/XFG in the sample (>0.05). CONCLUSION: Variations in gene may not be associated with XFS/XFG in the Jordanian population. More studies are required to confirm the current findings.
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Classification:
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
