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PURPOSE: To investigate whether the relationship between circumpapillary vascular density (cpVD) and visual field (VF) mean sensitivity (MS) differs between primary open-angle (POAG) and angle-closure glaucoma (PACG). METHODS: The cpVD and retinal nerve fiber layer thickness (RNFLT) were obtained using optical coherence tomography angiography (OCTA, AngioVue/RTVue-XR) in 146 eyes from 146 subjects (age- and VF mean deviation-matched 86 POAG and 60 PACG). Global and regional relationships (superotemporal [ST], superonasal [SN], nasoupper [NU], nasolower [NL], inferonasal [IN], inferotemoporal [IT], temporolower [TL], and temporoupper [TU] sectors) were estimated between cpVD and VF MS using multiple linear regression models controlling for the confounding variables in two disease categories. Uni- and multivariate linear regression models were built using cpVD as the dependent variable and covariates (age, intraocular pressure [IOP], axial length, signal strength index, and RNFLT) as independent variables. RESULTS: In PACG eyes, the cpVD was associated with the corresponding VF MS in five sectors (semipartial correlation coefficient [sr]: 0.144-0.567, P < 0.05): IN, IT, ST, TL, and SN, while the RNFLT showed association in four sectors (sr: 0.047-0.544, P < 0.05). In POAG eyes, the cpVD of all sectors was associated with the corresponding VF MS (sr: 0.246-0.574, P < 0.05). Greater IOP and lower RNFLT were independently associated with reduction of cpVD in the PACG group (P = 0.002, P < 0.001). In the meantime, only lower RNFLT was associated with reduction of cpVD in the POAG group (P < 0.001). CONCLUSIONS: POAG and PACG eyes differed in vascular-function relationship determined by OCTA and VF MS.
Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.
Full article9.3.2 Chronic primary angle closure glaucoma (pupillary block) (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
2.12 Choroid, peripapillary choroid, peripapillary atrophy (Part of: 2 Anatomical structures in glaucoma)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)