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Abstract #79755 Published in IGR 20-2
Effect of Mannitol on Intraocular Pressure in Vitrectomized and Non-vitrectomized Eyes: A Prospective Comparative Study
Ramachandra V; Chandran P; Philip R; Philip R; Arunaachalam V; Raman GVJournal of Glaucoma 2018; 0:
PURPOSE: To compare the effect of mannitol in reducing intraocular pressure (IOP) in vitrectomized and non-vitrectomized eyes. METHODS: Prospective comparative case study. Eyes with IOP ≥40▒mm Hg were included. Eyes which are vitrectomized and silicon oil filled were classified as group 1, and non-vitrectomized open angle eyes were classified as group 2. Mannitol (20%, 1▒g/kg) was administered intravenously over 30 minutes, and IOP was recorded at 30 minutes interval till 2 hours and at the 3 and 4 hour from the start of mannitol. RESULTS: Thirty eyes (patients) were recruited in each group. Mean (SD) IOP reduced from 48.5±5.2 to 43.7±8 at 30 minutes, 40.7±8.4 at 60 minutes, 37.3±9.6 at 90 minutes, 35.6±10.4 at 2 hours, 34±10.7 at 3 hours and 33±11.2▒mm Hg at 4 hours in group 1, and from 48.9±6.5 to 43.2±8.6 at 30 minutes, 40.2±7.8 at 60 minutes, 36.7±7.3 at 90 minutes, 35.1±7.7 at 2 hours, 34.2±8.8 at 3 hours and 35.7±9.4▒mm Hg at 4 hours in group 2. There was significant reduction in IOP at each time point compared to baseline in both the groups (P < 0.001). There was no significant difference in IOP between the 2 groups at each time point. CONCLUSIONS: Mannitol reduces IOP significantly in both vitrectomized and non-vitrectomized eyes.
Glaucoma Services, Aravind Eye Hospital, Coimbatore, India.
Full articleClassification:
9.4.11.5 Glaucomas associated with vitreoretinal surgery (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.11 Glaucomas following intraocular surgery)
11.6 Osmotic treatment (Part of: 11 Medical treatment)
6.1.3 Factors affecting IOP (Part of: 6 Clinical examination methods > 6.1 Intraocular pressure measurement; factors affecting IOP)
