advertisement
Abstract #79856 Published in IGR 20-2
Subcortical visual pathway may be a new way for early diagnosis of glaucoma
Sun Y; Huang W; Li F; Li H; Wang L; Huang Y; Zhang XMedical Hypotheses 2019; 123: 47-49
Glaucoma is the leading cause of irreversible blindness worldwide, which is now viewed as a disease of brain with pathogenesis not fully understood. The main diagnostic methods are examining the retinal nerve fiber layer through optical coherence tomography and investigating visual field defect, but these methods present disadvantages in clinical practice. Studies have shown that patients with glaucoma often suffer negative emotion like anxiety and depression which is related to abnormal or reduced amygdala. Moreover, selective reduction of fMRI responses to transient achromatic stimuli in the superficial layer of the superior colliculus was found in the early glaucoma patients. By summarizing previous studies, we developed a hypothesis: superior colliculus-pulvinar-amygdala subcortical visual pathway may be involved in the incidence or progression of glaucoma. Validating this hypothesis would further clarify the mechanism of glaucoma and lead to the development of a more sensitive method for making an early diagnosis of glaucoma.
The Ophthalmology and Brain Cognition Collaboration Research Center of Zhongshan Ophthalmic Center and SIAT, State Key Laboratory of Ophthalmology, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China; Department of Ophthalmology, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China.
Full articleClassification:
2.16 Chiasma and retrochiasmal central nervous system (Part of: 2 Anatomical structures in glaucoma)
6.30 Other (Part of: 6 Clinical examination methods)
