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Abstract #8009 Published in IGR 4-3
Incidence of iris colour change in latanoprost treated eyes
Teus MA; Arranz-Marquez E; Lucea-Suescun PBritish Journal of Ophthalmology 2002; 86: 1085-1088
AIMS: To determine the incidence of increased iris pigmentation in eyes treated with chronic latanoprost. This is an observational, cohort study. METHODS: The anterior segments of both eyes of 43 patients with glaucoma were photographed after unilateral latanoprost therapy. Two independent, masked observers analyzed the slides of both eyes of the study participants, and compared the iris pigmentation of both eyes of each patient using a stereo viewer. RESULTS: Thirty patients (69.7%) had a definite acquired iridial anisochromia; 15 (50%) had increased superficial iris pigmentation with a 'granular' appearance (type 1 change), and 15 (50%) had an increased 'stromal pigmentation', i.e., the affected iris appeared darker than the fellow eye, but without a 'granular' appearance (type 2 change). CONCLUSIONS: The incidence of increased iris pigmentation induced by latanoprost is much higher than previously reported. The high prevalence of mixed iris color found in this population and the fact that the patients studied were undergoing unilateral therapy may explain these results.
M.A. Teus, MD, Department of Ophthalmology, Principe de Asturias Hospital, University of Alcala, Alcala de Henares, Madrid, Spain. mteus@teleline.es
Classification:
14 Costing studies; pharmacoeconomics