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Abstract #80442 Published in IGR 20-3
Increased Aqueous Humor Symmetric Dimethylarginine Level in Patients with Primary Open Angle Glaucoma
Firat PG; Demirel EE; Demirel S; Dikci S; Turkoz Y; Ozyalın FCurrent Eye Research 2019; 44: 619-622
: To evaluate the asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine (L-Arg) levels both in plasma and aqueous humor of primary open angle glaucoma (POAG) patients and matched controls. : 25 primary open angle glaucoma patients and 42 control cases with senile cataract were included in the study. Plasma and aqueous humor ADMA, SDMA and L-Arg levels of the participants were measured by using liquid chromatography-tandem mass spectrometry. : A significant increase in aqueous humor SDMA level was detected in POAG patients compared with controls ( = 0.0115). No significant difference was detected in plasma and aqueous humor ADMA, L-Arg levels. : The aqueous humor levels of SDMA are found to be associated with POAG. The result of this current study supports the role of nitric oxide pathway in glaucoma.
a Department of Ophthalmology , Inonu University School of Medicine , Malatya , Turkey.
Full articleClassification:
3.7 Biochemistry (Part of: 3 Laboratory methods)
2.6.3 Compostion (Part of: 2 Anatomical structures in glaucoma > 2.6 Aqueous humor dynamics)