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Abstract #8085 Published in IGR 4-3
Protective action of nipradilol against ischemia-induced retinal damage in rats
Taniai M; Sato E; Mizota A; Adachi-Usami EOphthalmic Research 2002; 34: 331-337
The purpose of this study was to investigate whether nipradilol, an alfa 1-blocker, with both vasodilating and alfa 1-blocking activities, can protect retinal cells from the injury induced by ischemia and reperfusion. Rats were anesthetized and, after an intravitreal injection of nipradilol, the intraocular pressure (IOP) was raised for 45 minutes to induce retinal ischemia and reperfusion. Before, and three and seven days after, the ischemia, electroretinograms were recorded. After the ischemia, the mean amplitude of the b-waves in rats receiving 5 μl of 1.0 x 10-6 M nipradilol was significantly larger than of controls (injected with phosphate-buffered saline). Histologically, the reduction in the number of retinal ganglion cells (1.0 x 10-6 M), and the thickness of the inner and outer plexiform layers and the inner nuclear layer (1.0 x 10-6, 10-7 and 10-8 M) was suppressed by nipradilol. These results indicate that nipradilol protected the retina against retinal ischemia and reperfusion and should be considered for therapeutic use in cases of transient retinal ischemia.
Mariko Taniai, MD, Department of Ophthalmology and Visual Science, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. taniai@ophthalm.m.chiba-u.ac.jp
Classification:
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
