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Abstract #80850 Published in IGR 20-3
Randomized crossover trial comparing effectiveness and tolerability of generic and brand-name travoprost
Ta Kim D; Daigle P; Carbonneau MCanadian Journal of Ophthalmology 2019; 54: 223-228
OBJECTIVE: The primary goal is to determine if the intraocular pressure reducing effect of generic Sandoz travoprost is equivalent to that of brand-name Travatan Z. The secondary goal is to determine if generic Sandoz travoprost is as well tolerated as Travatan Z. METHODS: This prospective randomized crossover trial allocated 76 patients with primary open-angle glaucoma, normotensive glaucoma, or ocular hypertension in a 1:1 ratio to start with either generic Sandoz travoprost or Travatan Z. Crossover happened after 3 weeks. The primary endpoint, intraocular pressure, was measured in both eyes at baseline, at week 3, and at week 6. The secondary endpoint was tolerability of both drugs as assessed by a questionnaire administered at week 3 and week 6. RESULTS: The intraocular pressure lowering effect of generic Sandoz travoprost was equivalent to that of Travatan Z (18.20 ± 3.41 mmHg and 18.44 ± 3.48 mmHg respectively, p < 0.0001). Tolerability, as measured with a questionnaire, was similar between the two formulations of travoprost. CONCLUSION: This study is the first to compare a brand-name travoprost with one of its generic forms and adds to the body of evidence that generic glaucoma eye drops are as effective and well-tolerated as their brand name counterparts. The intraocular pressure lowering effect of generic Sandoz travoprost is equivalent to that of Travatan Z. Patient tolerance of generic and brand-name travoprost is similar.
Department of Ophthalmology, Centre Hospitalier Universitaire de Sherbrooke - Hôtel-Dieu, University of Sherbrooke, Sherbrooke, Quebec.. Electronic address: david.tri.ta.kim@gmail.com.
Full articleClassification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
