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Abstract #81027 Published in IGR 20-3
Longitudinal Macular Structure-Function Relationships in Glaucoma and Their Sources of Variability
Nouri-Mahdavi K; Fatehi N; Caprioli JAmerican Journal of Ophthalmology 2019; 207: 18-36
PURPOSE: 1) Review central structure-function (SF) relationships in glaucoma; 2) compare contributions of within-session and between-session variability to total variability of macular optical coherence tomography (OCT) thickness measurements; and 3) test the hypothesis that longitudinal within-eye variability of central SF relationships is smaller than between-individual variability. METHODS: We reviewed the pertinent literature on central SF relationships in glaucoma. Thirty-eight eyes (20 normal or glaucoma subjects) had ×3 macular images per session over 3 sessions and superpixels thickness measurements for ganglion cell layer (GCL), ganglion cell/inner plexiform layer (GCIPL), ganglion cell complex (GCC) and full macular thickness (FMT) were exported. Linear mixed models were used for estimating contributions of between- and within-session variability to total thickness variability. 120 eyes with ≥3 10° visual fields (VFs)/OCT images were enrolled for the longitudinal study. We investigated within-eye longitudinal SF relationships (GCIPL thickness vs. VF test locations) with a change-point regression model and compared within-eye with between-individual variabilities with components-of-variance models. RESULTS: In the cross-sectional study, between-session component contributed 8%, 11%, 11%, and 36% of total variability for GCL, GCIPL, GCC, and FMT. In the longitudinal study, between-individual variability explained 78%, 77%, and 67% of total SF variability at 3.4°, 5.6°, and 6.8° eccentricities (P<0.05). Structure-function relationships remained stable over time within individual eyes. CONCLUSIONS: Within-session variability accounts for most of macular thickness variability over time. Longitudinal within-eye SF variability is smaller than between-individual variability. Study of within-eye SF relationships could help clinicians better understand SF linking in glaucoma and help refine progression algorithms.
Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California. Electronic address: nouri-mahdavi@jsei.ucla.edu.
Full articleClassification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
6.6.2 Automated (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
