advertisement
Abstract #8113 Published in IGR 4-3
The clinical and pathological observations of neovascular glaucoma
Zhang H; Wang WChinese Ophthalmic Research 2002; 20: 319-322
OBJECTIVE: To observe the clinical and pathological changes of neovascular glaucoma (NVG) subsequent to retinal vein occlusion. METHODS: Four hundred and forty-five eyes of 429 cases of retinal vein occlusion were examined, including 385 eyes of 369 cases with central retinal vein occlusion (CRVO), and 60 eyes OF 60 cases of hemicentral retinal vein occlusion (H-CRVO). Of these, ischemic type was seen in 295 eyes, and nonischemic type in 150 eyes. Fluorescein angiography, trypsin digestion techniques, and microscopic examination were used to study neovascularization and pathological changes in NVG. Also, the incidence, risk factors, and visual prognosis of NVG were analyzed. RESULTS: RESULTS: Thirty-six of 445 eyes with retinal vein occlusion developed NVG, the incidence being 8.09%; CRVO 35 eyes (9. 09%); H-CRVO one eye (1.7%); and 36 eyes with NVG were the ishchemic type. In 32 cases with NVG (24 male, eight female 8), the average age was 43.0 years. Patients were followed-up for from three to 240 months; average, 31.6 months. The risk factors of NVG were as follows: 1. initial acuity was an important factor: initial acuity was lower than 0.1 in 63.9% with NVG and in 27.5% with non-NVG (p < 0.001). 2. Systemic factors: hypertension, coronary cardiac diseases 65.5%; hyperviscosity 46.9%. 3. Eye diseases: primary glaucoma 12.5%; retinal arteriosclerosis 40.6%; narrow retinal arteries 68.8%. Visual prognosis: the final visual acuity was poor in NVG from light perception to counting finger (24 eyes, 66.7%); 0.02 ˜ 0.05 in nine eyes (25.0%), 0.1 ˜ 0.4 in three eyes (8.3%); the rate of blindness was 91.7%. Pathological findings: the newly formed vessels originated from retinal capillaries. The endothelial cells proliferated by budding to form a solid mass at first, and developed new vessels with lumen. The new vessels grew in retinal posterior poles and equator. CONCLUSIONS: The risk factors for NVG are initial acuity, primary glaucoma, ischemia, hypertension, and hyperviscosity. The visual prognosis is poor, and the rate of blindness is high. LA: Chinese
H. Zhang, MD, Department of Ophthalmology, Third Hospital, Peking University, Beijing 100083, China
Classification:
9.4.5.1 Neovascular glaucoma (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.5 Glaucomas associated with disorders of the retina, choroid and vitreous)
