advertisement
Abstract #81204 Published in IGR 20-3
An association between large optic nerve cupping and cognitive function
Vajaranant TS; Hallak J; Espeland MA; Pasquale LR; Klein BE; Meuer SM; Rapp SR; Haan MN; Maki PMAmerican Journal of Ophthalmology 2019; 206: 40-47
PURPOSE: To determine if a larger cup-disc ratio is associated with poor cognitive function in postmenopausal women without glaucoma or ocular hypertension. METHODS: We used data from the Women's Health Initiative (WHI), originally designed to test effects of hormone therapy (HT) on various health outcomes. Large cup-disc ratio was defined as greater than 0.6 in either eye based on stereoscopic optic nerve photographs. Global cognitive function was assessed annually by Modified Mini-Mental State Examination (3MSE) in the WHI Memory Study. Exclusions were no information on optic nerve grading; no 3MSE scores at the time of the eye examination, ocular hypertension (IOP >23 mm Hg, Goldmann applanation tonometry), or glaucoma medication use. A generalized linear model for log-transformed 3MSE scores was used for determining the association between large cup-disc ratio and 3MSE scores, adjusting for age, race, diabetes, body mass index, cardiovascular disease, smoking, HT randomization, education, and diabetic retinopathy. RESULTS: Analyses included 1636 women (mean age ± SD, 69.57±3.64 years; 90.39% white). Of those, 122 women had large cup-disc ratio. The mean 3MSE scores in women with versus without large cup-disc ratio were 95.4±6 vs 96.6±5. In the adjusted model, women with large cup-disc ratio had statistically significant lower 3MSE scores, compared with those without large cup-disc ratio, yielding the predicted mean difference in 3MSE scores of 0.75 with a standard error of 0.05 units (P = 0.04). CONCLUSIONS: Postmenopausal women who had large cup-to-disc ratio without glaucoma or ocular hypertension exhibited lower global cognitive function. Further investigation is warranted.
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago. Electronic address: thasarat@uic.edu.
Full articleClassification:
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
