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Abstract #81313 Published in IGR 20-3
Vascular Inflammation Risk Factors in Retinal Disease
Soto I; Krebs MP; Reagan AM; Howell GRAnnual review of vision science 2019; 5: 99-122
Inflammation of the blood vessels that serve the central nervous system has been increasingly identified as an early and possibly initiating event among neurodegenerative conditions such as Alzheimer's disease and related dementias. However, the causal relevance of vascular inflammation to major retinal degenerative diseases is unresolved. Here, we describe how genetics, aging-associated changes, and environmental factors contribute to vascular inflammation in age-related macular degeneration, diabetic retinopathy, and glaucoma. We highlight the importance of mouse models in studying the underlying mechanisms and possible treatments for these diseases. We conclude that data support vascular inflammation playing a central if not primary role in retinal degenerative diseases, and this association should be a focus of future research.
Department of Molecular and Cellular Biosciences, Rowan University, Glassboro, New Jersey 08028, USA; email: sotoreyes@rowan.edu.
Full articleClassification:
3.10 Immunobiology (Part of: 3 Laboratory methods)
3.9 Pathophysiology (Part of: 3 Laboratory methods)
