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Abstract #81363 Published in IGR 20-3
Prediction of Glaucoma Progression with Structural Parameters: Comparison of Optical Coherence Tomography and Clinical Disc Parameters
Daneshvar R; Yarmohammadi A; Alizadeh R; Henry S; Law SK; Caprioli J; Nouri-Mahdavi KAmerican Journal of Ophthalmology 2019; 208: 19-29
PURPOSE: To test the hypothesis that baseline optical coherence tomography (OCT) measures predict visual field (VF) progression in a cohort of patients with suspected or established glaucoma and compare their performance to semiquantitative optic disc measures. DESIGN: Observational cohort study. METHODS: Setting: Academic institution. STUDY POPULATION: One-hundred seventy-one eyes of 95 patients with good-quality baseline retinal nerve fiber layer (RNFL) and macular OCT images and disc photographs with >2 years of follow-up and ≥5 VFs. OBSERVATION PROCEDURES: Baseline macular and RNFL OCT measures and cup-to-disc ratio and disc damage likelihood score. MAIN OUTCOME MEASURES: Prediction of glaucomatous visual field deterioration according to trend and event analyses. RESULTS: Median (IQR) baseline mean deviation and follow-up were -2.9 (-6.4 to -1.1) dB and 54 (44-65) months, respectively. Seventeen and 25 eyes progressed by final visit based on pointwise event analysis and trend analysis of Visual Field Index (VFI), respectively. Thinner CCT (p =0.005), female gender (p =0.015), and thinner average pRNFL (p =0.001) predicted VF progression on proportional hazard models. Thinner RNFL at baseline (p =0.006) or thinner average GCIPL (p =0.028) along with higher baseline VFI (p =0.018 and 0.048, respectively) predicted VFI progression. Neither optic disc measures predicted VF progression in any of the explored models. CONCLUSIONS: Baseline structural OCT measures predicted subsequent VF progression in contrast to semiquantitative optic disc measures. OCT-based structural measures should be included in prognostic models of glaucomatous VF deterioration.
Glaucoma Division, Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles; Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Full articleClassification:
6.20 Progression (Part of: 6 Clinical examination methods)
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
6.8.2 Posterior segment (Part of: 6 Clinical examination methods > 6.8 Photography)
