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Abstract #8146 Published in IGR 4-3
Photopic negative response of eyes with normal-tension glaucoma
Gotoh YNippon Ganka Gakkai Zasshi 2002; 106: 481-487
PURPOSE: The purpose of this study was to investigate the behavior of the photopic negative response (PhNR) of a cone-induced electroretinogram (cone ERG) in patients with normal-tension glaucoma (NTG). METHODS: Cone ERGs were recorded in 30 eyes of 30 patients with NTG, according to the recording conditions of the International Society for Clinical Electrophysiology of Vision protocol which is now widely used in clinics. The amplitudes and implicit times of the PhNRs were measured and compared with normal controls. The author further attempted to find a correlation between the PhNR amplitude loss and the cupping/disc ratio representing a loss of the nerve fiber layer and severity of visual field defect. RESULTS: The PhNR amplitudes recorded from patients with NTG were significantly reduced compared with those from normal subjects (p < 0.05). However, the PhNR amplitude loss did not correlate with the cupping/disc ratio or the severity of visual field defect. CONCLUSIONS: The results suggested that the PhNR amplitude qualitatively reflected ganglion cell loss in patients with NTG even under recording conditions which are widely used in the clinical field. LA: Japanese
Y. Gotoh, MD, Department of Ophthalmology, Iwate Medical University School of Medicine, 19-1 Uchimaru, Morioka 020-8505, Japan
Classification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)
