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Abstract #82006 Published in IGR 20-4
Role of Pattern Electroretinogram in Ocular Hypertension and Early Glaucoma
Turkey E; Elsanabary ZSE; Elshazly LHM; Osman MHJournal of Glaucoma 2019; 28: 871-877
PURPOSE: To test whether pattern electroretinogram (PERG) can early detect retinal ganglion cells dysfunction in ocular hypertension. DESIGN: Cross-sectional observational study. PARTICIPANTS: The study included 3 groups: control, primary open-angle glaucoma (POAG) and ocular hypertension (OHT) groups with 30 eyes in each group. MATERIALS AND METHODS: Visual fields were examined using automated perimetry with central 24-2 program. Optical coherent tomography (OCT) was done to assess the neuroretinal rim area, vertical cup/disc ratio, and average superior and inferior retinal nerve fiber layer thickness. PERG was recorded using skin electrodes. Amplitude and latency of P50 and N95 were documented. RESULTS: PERG data: the mean P50 and N95 latency were significantly higher in the POAG group and the OHT group compared with the control group (P<0.001, <0.001, respectively). Also, the mean P50 and N95 amplitude were significantly lower in the POAG group and the OHT group compared with the control group (P<0.001,<0.001, respectively). In the POAG group, there was a significant negative correlation between PSD on one hand and P50 amplitude (r=-0.620, P=0.001) and N95 amplitude (r=-0.61, P<0.001) on the other hand. Also, the mean deviation was positively correlated with P50 amplitude (r=0.51, P=0.007) and N95 amplitudes (r=0.50, P=0.002). However, there was no significant correlation between PERG parameters and OCT parameters. In the OHT group, PERG parameters did not correlate with visual field and OCT parameters. CONCLUSIONS: PERG can detect the dysfunctional, but still live retinal ganglion cells earlier than OCT in OHT cases, allowing the early start of treatment that can restore the ganglion cell function before irreversible damage occurs.
Memorial Institute of Ophthalmic Research.
Full articleClassification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)
