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1 General aspects (1)   1.1 Epidemiology (14)   1.2 Population genetics (2)   1.3 Pathogenesis (1)   1.4 Quality of life (20)   1.5 Glaucomas as cause of blindness (8)   1.6 Prevention and screening (13) 2 Anatomical structures in glaucoma (0)   2.1 Conjunctiva (10)   2.2 Cornea (23)   2.3 Sclera (16)   2.4 Anterior chamber angle (7)   2.5 Meshwork (0)     2.5.1 Trabecular meshwork (15)     2.5.2 Schlemms canal (1)     2.5.3 Scleral outlet channels (1)   2.6 Aqueous humor dynamics (0)     2.6.1 Production (0)     2.6.2 Outflow (1)       2.6.2.1 Trabecular meshwork (4)       2.6.2.2 Uveoscleral (1)     2.6.3 Compostion (6)   2.7 Episcleral veins and venous pressure (2)   2.8 Iris (6)   2.9 Ciliary body (0)   2.10 Lens (0)   2.11 Vitreous body (0)   2.12 Choroid, peripapillary choroid, peripapillary atrophy (18)   2.13 Retina and retinal nerve fibre layer (37)   2.14 Optic disc (42)   2.15 Optic nerve (2)   2.16 Chiasma and retrochiasmal central nervous system (13)   2.17 Stem cells (5)   2.20 Other (0) 3 Laboratory methods (0)   3.1 Microscopy (0)   3.2 Electron microscopy (2)   3.3 Immunohistochemistry (2)   3.4 Molecular genetics (0)     3.4.1 Linkage studies (0)     3.4.2 Gene studies (30)   3.5 Molecular biology incl. 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Abstract #82239 Published in IGR 20-4

Leucaena leucocephala (Lam.) galactomannan nanoparticles: Optimization and characterization for ocular delivery in glaucoma treatment

Mittal N; Kaur G
International Journal of Biological Macromolecules 2019; 139: 1252-1262

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In the present study, bioadhesive polymeric nanoparticles for ocular delivery of dorzolamide hydrochloride (DRZ) were formulated using derivatized Leucaena leucocephala galactomannan (LLG). The carboxymethyl (CMLLG) and amine derivative (AMLLG) of LLG were synthesized and used for the preparation of nanoparticles. The preparation method was optimized using 2-factor, 3-level central composite experimental design. The optimized nanoparticles were characterized by FTIR, DSC, SEM, TEM and XRD studies. The results of in vitro release studies and ex vivo transcorneal permeation studies revealed sustained release and higher corneal permeation as compared to conventional formulation of DRZ. The optimized nanoparticles were found to reduce the intra ocular pressure (IOP) for prolonged period of time when compared to conventional eye drops. Overall, the present study suggests a promising role of bioadhesive polymeric nanoparticles for ocular drug delivery in glaucoma treatment.

Department of Pharmaceutical Sciences and Drug Research, Punjabi University, Patiala 147002, Punjab, India.

Full article

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Classification:

11.16 Vehicles, delivery systems, pharmacokinetics, formulation (Part of: 11 Medical treatment)
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)

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