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Abstract #8230 Published in IGR 4-3
Intraocular pressure elevation after subtenon injection of triamcinolone acetonide during uveitis
Bui Quoc E; Bodaghi B; Adam R; Burtin T; Cassoux N; Dreifuss S; Fardeau C; LeHoang PJournal Français d'Ophtalmologie 2002; 25: 1048-1056
INTRODUCTION: New therapeutic concepts in the management of ocular inflammation have led to the development of periocular and intravitreal injections. Such treatment modalities can induce intraocular pressure (IOP) elevation. PATIENTS AND METHODS: Periocular injections were given to patients suffering from strictly unilateral or bilateral but asymmetrical and noninfectious posterior uveitis. A history of corticosteroid-induced glaucoma was a contraindication to such treatment. A retrospective review of cases who were given subtenon triamcinolone acetonide injection between May and October 2001 was undertaken to evaluate the efficacy of the treatment and the risk of IOP elevation. Ocular pressure was measured before and after the injection and the efficacy of the treatment was evaluated by measurements of visual acuity and fluorescein angiography. RESULTS: One or several injections were given to 61 patients, IOP rose in 13 patients (21.3%). medical treatment was unsuccessful in three cases and surgical excision of periocular corticosteroid deposit was required. Therefore, IOP was controlled with no other medication. Treatment was considered effective in 32 patients (52.45%): improvement of visual acuity (of more than two lines) or control of inflammation on fluorescein angiography. DISCUSSION AND CONCLUSIONS: Periocular subtenon injection of triamcinolone acetonide in posterior noninfectious uveitis is a safe procedure. IOP elevation is not frequent and can be controlled through medical treatment or surgical excision of a residual deposit, in which pharmacologically-active triamcinolone can be present several months after the injection.LA: French
P. LeHoang, MD, Service d'Ophtalmologie, Groupe Hospitalier Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75651 Paris Cedex 13, France. bahram.bodaghi@psl.ap-hop-paris.fr
Classification:
9.4.6 Glaucomas associated with inflammation, uveitis (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
11.15 Other drugs in relation to glaucoma (Part of: 11 Medical treatment)