advertisement
Abstract #82627 Published in IGR 20-4
Normal tension glaucoma-like degeneration of the visual system in aged marmosets
Noro T; Namekata K; Kimura A; Azuchi Y; Hashimoto N; Moriya-Ito K; Komaki Y; Lee CY; Okahara N; Guo X; Harada C; Kim E; Nakano T; Tsuneoka H; Inoue T; Sasaki E; Tokuno H; Harada TScientific reports 2019; 9: 14852
The common marmoset (Callithrix jacchus) is a non-human primate that provides valuable models for neuroscience and aging research due to its anatomical similarities to humans and relatively short lifespan. This study was carried out to examine whether aged marmosets develop glaucoma, as seen in humans. We found that 11% of the aged marmosets presented with glaucoma-like characteristics; this incident rate is very similar to that in humans. Magnetic resonance imaging showed a significant volume loss in the visual cortex, and histological analyses confirmed the degeneration of the lateral geniculate nuclei and visual cortex in the affected marmosets. These marmosets did not have elevated intraocular pressure, but showed an increased oxidative stress level, low cerebrospinal fluid (CSF) pressure, and low brain-derived neurotrophic factor (BDNF) and TrkB expression in the retina, optic nerve head and CSF. Our findings suggest that marmosets have potential to provide useful information for the research of eye and the visual system.
Full article
Classification:
5.2 Primates (Part of: 5 Experimental glaucoma; animal models)
9.2.4 Normal pressure glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
