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Abstract #8270 Published in IGR 4-3
Exfoliation syndrome: frequency, gender distribution and association with climatically induced alterations of the cornea and conjunctiva
Forsius H; Forsman E; Fellman J; Eriksson AWActa Ophthalmologica Scandinavica 2002; 80: 478-484
PURPOSE: To investigate the exfoliation syndrome (ES) in order to elucidate gender distribution and the roles of genetic and climatic factors in its manifestation. MATERIAL AND METHODS; The authors studied the gender distribution of ES and the association between ES and the appearance of certain climatically-induced disorders (pterygium, climatic droplet keratopathy), and the size of pingueculae in populations living in the Arctic region, in temperate regions, and in tropical regions. This involved a total of 11 samples taken in eight different countries, comprising 2206 persons of both genders aged over 50 years. RESULTS: A total of 1051 males were investigated for ES, 147 of whom (14.0%) were found to have it. The corresponding figures for females were 1093 and 177 (16.2%). After standardization according to age, no systematic difference between the genders was found in the study. The frequency of ES varied greatly. It was not observed at all in the Inuit (Eskimos), but was found most frequently (about 30%) in the Saami (Lapps), Aland Islanders, Finns, Icelanders, and Russians over 70 years of age. Over the age of 50 years, the frequency of ES increases rapidly with age in all populations. However, the curves for ES in people living in the tropics show a delay of about ten years. In contrast, the frequency of climatically-caused changes (pterygium, climatic keratopathy, and pronounced pinguecula) mostly peaks at the age of 50 years, and is highest in the tropics and the Arctic. Males in these regions tended to be more affected by climatically-caused changes than females. Likewise, in tropical climates, where radiation from the sun is strong, and in Lapland and Novosibirsk, where there is radiation from snow, males showed more evidence of ES than females. however, examination of 506 patients from a private practice in South Finland, who were under observation for glaucoma or for risk of glaucoma, showed that the majority of those with ES were females. CONCLUSIONS: As a rule, climate does not appear to influence the occurrence of ES. However, in tropical countries, where radiation from the sun is strong, ES was more common in males than in females. In the light of its peculiar population distribution, even when climatic factors are considered, there would appear to be an important genetic factor involved in the manifestation of ES.
H. Forsius, MD, Folkhälsan Institute of Genetics, Population Genetics Unit, Helsinki, Finland
Classification:
9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)