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Abstract #8273 Published in IGR 4-3
A comparison of the effects on intraocular pressure of latanoprost 0.005% and the fixed combination of dorzolamide 2% and timolol 0.5% in patients with open-angle glaucoma
Honrubia EM; Larsson LI; Spiegel D; European Latanoprost Study GroupActa Ophthalmologica Scandinavica 2002; 80: 635-641
PURPOSE: To compare the effects on intraocular pressure (IOP) of latanoprost 0.005% and the fixed combination of dorzolamide 2% and timolol 0.5%. METHODS: Overall, 226 patients whose IOP was insufficiently controlled by timolol alone were randomized to receiving either latanoprost once daily or the fixed combination of dorzolamide plus timolol twice daily. IOP was measured at 10:00 a.m. and 5:00 p.m. at baseline and after three months of treatment. RESULTS: Mean IOP was reduced from baseline in both groups (p < 0.001), with a mean ± SEM reduction of -4.3 ± 0.3 mmHg (19%) for the latanoprost treatment group and -4.0 ± 0.3 mmHg (17%) for the dorzolamide plus timolol treatment group. The two therapies were similarly effective in lowering IOP levels (mean difference in reduction: -0.4 ± 0.4; 95% confidence interval: -1.1, 0.4). CONCLUSIONS: Monotherapy with latanoprost once daily was as effective in reducing mean IOP as the fixed combination of dorzolamide plus timolol twice daily in patients with IOP insufficiently controlled by timolol alone.
E.M. Honrubia, MD, Hospital Miguel Servet, Servicio de Oftalmologia, Zaragoza, Spain
Classification:
11.4 Prostaglandins (Part of: 11 Medical treatment)
11.3.4 Betablocker (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)
11.5.2 Topical (Part of: 11 Medical treatment > 11.5 Carbonic anhydrase inhibitors)
