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Abstract #8283 Published in IGR 4-3
Retinal nerve fiber layer thickness in glaucomatous eyes: a comparative study between OCT and visual field
Moreno-Montanes J; Alvarez-Vidal A; Sainz-Gomez C; Rodriguez-Conde RArchivos de la Sociedad Española de Oftalmologia 2002; 77: 435-441
PURPOSE: To investigate the retinal nerve fiber layer (RNFL) thickness in glaucomatous eyes using optical coherence tomography (OCT). To compare the RNFL thickness with visual field damage (Humphrey Field Analyzer). MATERIAL AND METHODS: The mean RNFL thickness in glaucomatous eyes (n = 80) was compared with age-matched normal eyes (n = 40). Three circular scans were obtained for each eye using OCT (3.4 mm diameter). In each eye, average RNFL, four quadrants, and 12 meridians, were calculated and compared. The superior-inferior asymmetry of RNFL was studied. The average RNFL thickness was compared with mean deviation (MD) and mean standard deviation (MSD) of SITA 24-2 visual field program. RESULTS: Mean RNFL was significantly thinner in glaucomatous eyes than in normal eyes (p < 0.001). The RNFL thickness was decrease in the four quadrants and 11 of 12 meridians studied in glaucomatous eyes (p < 0.05). The superior-inferior asymmetry showed a significant difference in RNFL thickness at 30 degrees central meridian (p < 0.05). Mean RNFL thickness was significantly associated with DM and DSM of visual field (p < 0.001) in glaucomatous eyes. CONCLUSIONS: OCT revealed significant quantitative differences in RNFL thickness between glaucomatous and normal eyes. OCT showed a considerable measurements overlap between glaucomatous and normal eyes, which can limit the sensitivity and specificity of this instrument. LA: Spanish
J. Moreno-Montanes, MD, Departamento de Oftalmologia, Clinica Universitaria, Universidad de Navarra, Pamplona, Spain. jmoreno@unav.es
Classification:
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
6.6.3 Special methods (e.g. color, contrast, SWAP etc.) (Part of: 6 Clinical examination methods > 6.6 Visual field examination and other visual function tests)
6.9.2 Optical coherence tomography (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis)
