advertisement
Abstract #8314 Published in IGR 4-3
Effects of anti-glaucoma medications on ganglion cell survival: the DBA/2J mouse model
Schuettauf F; Quinto K; Naskar R; Zurakowski DVision Research 2002; 42: 2333-2337
The authors studied whether several agents, approved or undergoing trials in human glaucoma, were effective in preventing ganglion cell loss in the DBA/2J mouse. Adult DBA/2J mice were treated with timolol, pilocarpine, brimonidine, dorzolamide, or NMDA-receptor antagonist memantine. Surviving retinal ganglion cells of treated and control mice were retrogradely labelled with fluorogold and counted after whole mount preparation. In treated mice, only memantine and timolol had significant effects on retinal ganglion cell survival (p < 0.0001, analysis of variance). Brimonidine was lethal to these mice, and these retinae were not analyzed further. The DBA/2J mouse represents a promising candidate for further experimentation in ocular hypertension.
F. Schuettauf, MD, Department of Ophthalmology, Scheie Eye Institute, University of Pennsylvania, 51 North 39th Street, Philadelphia, PA 19104, USA. fschuettauf@uni-tuebingen.de
Classification:
5 Experimental glaucoma; animal models
11.8 Neuroprotection (Part of: 11 Medical treatment)
