advertisement
Abstract #8349 Published in IGR 4-3
The relationship between age and intraocular pressure in a Japanese population: the influence of central corneal thickness
Nomura H; Ando F; Niino N; Shimokata H; Miyake YCurrent Eye Research 2002; 24: 81-85
PURPOSE: Previous cross-sectional Japanese studies have shown that intraocular pressure (IOP) decreases with age. However, central corneal thickness (CCT) variation should also be considered when examining the relationship between age and IOP, since tonometry has an inherent measurement error due to CCT variations. This study investigates the influence of CCT variation on the age-IOP relationship in a Japanese population. METHODS: The right eyes of 1317 subjects aged from 40-80 years, selected from a general population using a random sampling method, were assessed in cross-section. IOP was measured with a non-contact tonometer, and CCT was measured with a specular microscope. The relationships between age, IOP, and CCT were assessed using correlation analyses, while the relationship between age and IOP controlled for CCT, blood pressure, and body mass index was investigated using multivariate regression analyses. RESULTS: The mean (± SD) IOP value was 13.6 (± 2.6) mmHg in males and 13.3 (± 2.6) mmHg in females. The IOP correlated inversely with age in men (r = -0.14, p < 0.001), but showed only a marginal inverse correlation in women (r = -0.07, p = 0.066). The mean (± SD) CCT value was 518.3 (± 33.2) μm in males and 511.1 (± 33.0) μm in females. Only in males was an inverse correlation seen between CCT and age (r = -0.10, p = 0.009), but both genders had positive correlations between CCT and IOP (male: r = 0.44, p < 0.001; female: r = 0.48, p < 0.001). In multivariate analyses, CCT was shown to have an effect on IOP measurement, however, it was shown that IOP still decreases with age in both sexes even when adjusted for CCT (p = 0.001). CONCLUSIONS: IOP decreases with age in Japanese subjects, and CCT variation has practically no effect on the unique age-IOP relationship.
H. Nomura, MD, Department of Ophthalmology, Chubu National Hospital, Obu, Aichi, Japan. nomura@nils.go.jp
Classification:
6.1 Intraocular pressure measurement; factors affecting IOP (Part of: 6 Clinical examination methods)
