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Abstract #8437 Published in IGR 5-1
Cortical OFF-potentials from the S-cone pathway reveal neural damage in early glaucoma
Aldebasi YH; Drasdo N; Morgan JE; North RVVision Research 2003; 43: 221-226
The authors used background adaptation and silent substitution techniques to record full-field ON and OFF-visually evoked cortical potentials (VECPs) selectively from the S-cone and L- and M-cone pathways in 15 patients with primary open-angle glaucoma (POAG), and 15 normal controls. The most statistically significant (p = 0.01) VECP test for POAG was a voltage change in the S-cone pathway cortical OFF-response. A sensitivity of 93% was achieved, with 60% specificity at minimum error rate. This is presumed to reflect reduced activity in the S-cone and magnocellular visual pathways, and may provide an effective method for research and monitoring change in early glaucoma.
Dr. N. Drasdo, Department of Optometry and Vision Sciences, Cardiff University, Redwood Building, King Edward VII Avenue, Cardiff CF10 3YJ Wales, UK. neville@drasdo.co.uk
Classification:
6.7 Electro-ophthalmodiagnosis (Part of: 6 Clinical examination methods)
