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Abstract #84558 Published in IGR 21-1
Association of Ambient Particulate Matter Exposure with the Incidence of Glaucoma in Childhood
Min KB; Min JYAmerican Journal of Ophthalmology 2020; 211: 176-182
PURPOSE: We investigated whether exposure to air pollution, particularly to particles with a mass median aerodynamic diameter of ≤10 μm (PM), is associated with diagnosis of childhood glaucoma. DESIGN: Retrospective cohort study. METHODS: From the National Health Insurance Service-National Sample Cohort, a total of 9004 infants born between January 2002 and December 2002 were included and followed-up for an 11-year period (2003-2012). Patients with glaucoma were defined as International Classification of Diseases, 10th revision code H40. Exposure levels of PM were extrapolated using geographic information systems, and individual exposure levels were assigned. RESULTS: During the study period, glaucoma occurred in 85 patients (0.94%). The probability of developing childhood glaucoma increased with the increase in PM quartiles. Increases in 1 μg/m of long-term PM were significantly associated with increased hazard ratios (HRs) for childhood glaucoma (HR = 1.22 [95% confidence interval {CI} 1.15-1.28]). Compared with risk of the lowest PM exposure group (quartile 1), the adjusted HRs for childhood glaucoma were significant in the highest PM exposure group of quartile 4 (HR = 2.84 [95% CI 1.37-5.89]) in model 3. Regarding the long-term PM exposure, the estimated hazard was considerably elevated in quartile 4 (HR = 6.61 [95% CI 2.96-14.75]). CONCLUSIONS: Short-term and long-term exposure to PM was associated with the incidence of childhood glaucoma. This finding confirms previous reports on the link between air pollution and ocular disease and suggests that PM exposure may be a risk for childhood glaucoma.
Department of Preventive Medicine, College of Medicine, Seoul National University, Seoul, Republic of Korea.
Full articleClassification:
9.1.2 Juvenile glaucoma (Part of: 9 Clinical forms of glaucomas > 9.1 Developmental glaucomas)
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
1.1 Epidemiology (Part of: 1 General aspects)