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Abstract #84571 Published in IGR 21-1
Heavy metal toxicity and the aetiology of glaucoma
Vennam S; Georgoulas S; Khawaja A; Chua S; Strouthidis NG; Foster PJEye 2020; 34: 129-137
Despite recent advances, our understanding of the aetiological mechanisms underlying glaucoma remains incomplete. Heavy metals toxicity has been linked to the development of neurodegenerative diseases and various ocular pathologies. Given the similarities in pathophysiology between glaucoma and some neurodegenerative disorders, it is plausible that heavy metal toxicity may play a role in the development of glaucoma. Heavy metal exposure may be occupational, or through water or dietary contamination. In this report, we review mechanisms for systemic and neurotoxicity for arsenic, cadmium, chromium, cobalt, lead, mercury, and manganese, and weigh the evidence for an association between glaucoma and the accumulation of heavy metals either in ocular tissues or in the central nervous system.
UCL Institute of Ophthalmology, 11-43 Bath Street, London, EC1V 9E, UK.
Full articleClassification:
9.2.2 Other risk factors for glaucoma (Part of: 9 Clinical forms of glaucomas > 9.2 Primary open angle glaucomas)
3.6 Cellular biology (Part of: 3 Laboratory methods)