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Abstract #84622 Published in IGR 21-1

Corneal endothelial cell loss following cataract surgery in patients with pseudoexfoliation syndrome: a 2-year prospective comparative study

Kristianslund O; Pathak M; Østern AE; Drolsum L
Acta Ophthalmologica 2020; 98: 337-342

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PURPOSE: To compare the corneal endothelial cell density (ECD) before and after cataract surgery in patients with and without pseudoexfoliation syndrome (PEX). METHODS: In this prospective study, we compared the ECD in 62 PEX patients with 62 patients without PEX (controls). The mean age was 78.3 ± 6.2 years and 77.2 ± 5.9 years, respectively. Patients were examined before and at 6 months, 1 year and 2 years after cataract surgery. The corneal endothelium was examined with confocal microscopy, and the ECD was counted both automatically and semi-manually. Nine patients in the PEX group (15%) and 11 patients in the control group (18%) were lost to follow-up in the 2-year period. Within the PEX and the control groups, we also compared the ECD between patients with and without glaucoma. RESULTS: Before surgery, the ECD (semi-manual counting) was 2258 ± 342 cells/mm in the PEX group and 2322 ± 321 cells/mm in the control group (p = 0.29). There were no significant differences in postoperative ECD between these groups at any visit. After 2 years, the ECD had changed by -679 ± 337 cells/mm and -704 ± 484 cells/mm , respectively (p = 0.78). The preoperative ECD was lower in eyes with glaucoma compared to eyes without glaucoma, both within the PEX group (p = 0.05) and the control group (p = 0.03). After surgery, there were no differences between eyes with or without glaucoma. CONCLUSION: The ECD was not significantly different in PEX eyes compared with control eyes, neither before nor after cataract surgery. However, there seemed to be a lower ECD in eyes with glaucoma before surgery.

Department of Ophthalmology, Oslo University Hospital, Oslo, Norway.

Full article

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Classification:

9.4.4.1 Exfoliation syndrome (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders > 9.4.4 Glaucomas associated with disorders of the lens)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)

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