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Abstract #84697 Published in IGR 21-1
Association between peripapillary scleral deformation and choroidal microvascular circulation in glaucoma
Shin DY; Jeon SJ; Kim EK; Jung KI; Park HYL; Park CKScientific reports 2019; 9: 18503
Peripapillary vessel density, which is reduced in eyes with glaucoma, has been proposed as a diagnostic tool for the desease and peripapillary choroidal microvasculature dropout(MvD) is considered one of pathophysiological manifestation of glaucomatous damage. However, little is known about the underlying pathogenic mechanism of dropout. According to recent studies, MvD is associated with structural changes in ONH structures. Therefore, we investigated the association between peripapillary scleral deformation and MvD. Data from 62 open-angle glaucoma (OAG) eyes with MvD and 36 eyes without MvD were analyzed in this study. And eyes with MvD were classified into two groups based on location: a juxtapapillary group and a non-juxtapapillary group for further analysis. More eyes with MvD had focal scleral deformation than did those without MvD (64.5% versus 2.8%; P < 0.001). Peripapillary choroidal thickness and focal scleral deformation were significantly associated with MvD. And juxtapapillary group was more associated with focal scleral deformation and coincidental RNFL defects than non-juxtapapillary groups. Peripapillary choroidal MvD was associated with the presence of scleral deformation, especially with juxtapapillary MvD, which was related to corresponding RNFL defects.
Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Full articleClassification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
2.12 Choroid, peripapillary choroid, peripapillary atrophy (Part of: 2 Anatomical structures in glaucoma)
2.2 Cornea (Part of: 2 Anatomical structures in glaucoma)
