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Abstract #84825 Published in IGR 21-1
Measurement of Retinal Microvascular Blood Velocity Using Erythrocyte Mediated Velocimetry
Tracey BM; Mayo LN; Le CT; Chen VY; Weichsel J; Renner CY; Li J; Tsai JJ; Kalarn SP; Ou MT; Chang LY; Mohammed TK; Mohammed ISK; Shah KA; Thompson GM; Jones AMK; Im LT; Kaleem MA; Saeedi OJScientific reports 2019; 9: 20178
Changes in retinal blood flow may be involved in the pathogenesis of glaucoma and other ocular diseases. Erythrocyte mediated velocimetry (EMV) is a novel technique where indocyanine green (ICG) dye is sequestered in erythrocyte ghosts and autologously re-injected to allow direct visualization of erythrocytes for in vivo measurement of speed. The purpose of this study is to determine the mean erythrocyte speed in the retinal microvasculature, as well as the intravisit and intervisit variability of EMV. Data from 23 EMV sessions from control, glaucoma suspect, and glaucoma patients were included in this study. In arteries with an average diameter of 43.11 µm ± 6.62 µm, the mean speed was 7.17 mm/s ± 2.35 mm/s. In veins with an average diameter of 45.87 µm ± 12.04 µm, the mean speed was 6.05 mm/s ± 1.96 mm/s. Intravisit variability, as measured by the mean coefficient of variation, was 3.57% (range 0.44-9.68%). Intervisit variability was 4.85% (range 0.15-8.43%). EMV may represent reliable method for determination of retinal blood speed, potentially allowing insights into the effects of pharmacologic agents or pathogenesis of ocular diseases.
University of Maryland School of Medicine, Baltimore, Maryland, United States.
Full articleClassification:
6.11 Bloodflow measurements (Part of: 6 Clinical examination methods)
6.10.2 Posterior segment (Part of: 6 Clinical examination methods > 6.10 Fluorescein (ICG) angiography)
