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PURPOSE: The authors report an unusual paradoxical effect of brimonidine. DESIGN: Observational case report. METHODS: A 70-year-old woman with bilateral normal tension glaucoma was treated with topical brimonidine and followed in an outpatient setting. The main outcome measured was intraocular pressure (IOP) in mmHg. RESULTS: Brimonidine was observed to cause IOP elevation, confirmed on rechallenge, scoring 8 (strong probability) on an adverse drug reaction probability score. CONCLUSION: In certain circumstances, topical brimonidine can cause paradoxical raised IOP necessitating vigilance in follow-up of patients on topical brimonidine.
Dr. B. Mushtaq, Birmingham and Midland Eye Centre, Birmingham University Hospital Selly Oak, UK
11.3.3 Apraclonidine, brimonidine (Part of: 11 Medical treatment > 11.3 Adrenergic drugs)