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Abstract #84861 Published in IGR 21-1
OCT Structural Abnormality Detection in Glaucoma using Topographically Correspondent Rim and Retinal Nerve Fiber Layer Criteria
Yang H; Luo H; Hardin C; Wang YX; Jeoung JW; Albert C; Vianna JR; Sharpe GP; Reynaud J; Demirel S; Mansberger SL; Fortune B; Nicolela M; Gardiner SK; Chauhan BC; Burgoyne CFAmerican Journal of Ophthalmology 2019; 0:
PURPOSE: To evaluate the ability of topographically correspondent (TC) minimum rim width (MRW) and peripapillary retinal nerve fiber layer thickness (pRNFLT) criteria to detect optical coherence tomography (OCT) structural abnormality in glaucoma (GL) and glaucoma suspect (GLS) eyes. DESIGN: Retrospective cross-sectional study. METHODS: 196 GL, 150 GLS eyes and 303 Heathy eyes underwent PRNFL and 24 radial optic nerve head OCT imaging and manual correction of the internal limiting membrane, Bruch's membrane opening (BMO) and outer pRNFL segmentations. MRW and pRNFLT were quantified in six Garway-Heath (GH) or twelve 30° (clock-hour) sectors. OCT abnormality for each parameter was defined to be < the 5 percentile of the Healthy eye distribution. OCT abnormality for individual eyes was defined using global, sectoral and combined-parameter criteria that achieved ≥ 95% specificity in the Healthy eyes. TC combination criteria required the sectoral location of MRW and pRNFLT abnormality to be topographically aligned and included comMR (MRW + pRNFLT x (Average MRW Healthy eyes / Average pRNFLT Healthy eyes). RESULTS: TC sectoral criteria (1 GH MRW + corresponding GH RNFLT), (1 30° MRW + any 1 corresponding or adjacent 30° pRNFLT), 30⁰ and GH comMR and global comMR were the best performing criteria, demonstrating: (96-99% specificity); 86-91% sensitivity for GL; 80-84% sensitivity for early GL (MD ≥ -4.0 dB) and 93-96% sensitivity for moderate-to-advanced GL (MD < -4.0 dB). CONCLUSIONS: Clinically intuitive TC MRW and pRNFLT combination criteria identified the sectoral location of OCT abnormality in GL eyes with high diagnostic precision.
Devers Eye Institute, Optic Nerve Head Research Laboratory, Legacy Research Institute, Portland, OR, USA; Devers Eye Institute, Discoveries in Sight Research Laboratories, Legacy Research Institute, Portland, OR 97208-3950, USA.
Full articleClassification:
6.9.2.2 Posterior (Part of: 6 Clinical examination methods > 6.9 Computerized image analysis > 6.9.2 Optical coherence tomography)
2.13 Retina and retinal nerve fibre layer (Part of: 2 Anatomical structures in glaucoma)
2.14 Optic disc (Part of: 2 Anatomical structures in glaucoma)
