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Abstract #84908 Published in IGR 21-1
Involvement of regulated necrosis in blinding diseases: Focus on necroptosis and ferroptosis
Peng JJ; Song WT; Yao F; Zhang X; Peng J; Luo XJ; Xia XBExperimental Eye Research 2020; 191: 107922
Besides apoptosis, necrosis can also occur in a highly regulated and genetically controlled manner, defined as regulated necrosis, which is characterized by a loss of cell membrane integrity and release of cytoplasmic content. Depending on the involvement of its signal pathway, regulated necrosis can be further classified as necroptosis, ferroptosis, pyroptosis and parthanatos. Numerous studies have demonstrated that regulated necrosis is involved in the pathogenesis of many diseases covering almost all organs including the brain, heart, liver, kidney, intestine, blood vessel, eye and skin, particularly myocardial infarction and stroke. Most recently, growing evidence suggests that multiple types of regulated necrosis contribute to the degeneration of retinal ganglion cells, retinal pigment epithelial cells or photoreceptor cells, which are the main pathologic features for glaucoma, age-related macular degeneration or retinitis pigmentosa, respectively. This review focuses on the involvement of necroptosis and ferroptosis in these blinding diseases.
Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, 410008, China; Department of Laboratory Medicine, The Third Xiangya Hospital of Central South University, Changsha, 410013, China.
Full articleClassification:
3.6 Cellular biology (Part of: 3 Laboratory methods)
3.9 Pathophysiology (Part of: 3 Laboratory methods)
