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Abstract #85017 Published in IGR 21-1

Effect of an oral supplementation with a formula containing R-lipoic acid in glaucoma patients

Sanz-González SM; Raga-Cervera J; Aguirre Lipperheide M; Zanón-Moreno V; Chiner V; Ramírez AI; Pinazo-Durán MD
Archivos de la Sociedad Española de Oftalmologia 2020; 95: 120-129

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OBJECTIVE: To analyse the safety and effectiveness of the oral administration of a commercialised supplement containing R-alpha lipoic acid, taurine, vitamins C and E, lutein, zeaxanthin, zinc, copper and docosahexaenoic acid, in patients with primary open angle glaucoma (POAG), and in control subjects. MATERIAL AND METHODS: A prospective study of cases and controls was carried out, including 30 participants of both genders that were divided into: POAG Group (n=15) and a control group (CG; n=15), assigned to the oral intake of NuaDHA preparations Vision® (1 pill/day)+NuaDHA 1000 (2 pills/day) for 6 months. Participants were interviewed, ophthalmologically examined, and peripheral blood was taken for routine analysis and the determination of the pro-oxidant (malondialdehyde) and total antioxidant status. Statistical analysis was performed using the SPSS 22.0 program. RESULTS: After 6 months of supplementation, there was a significant increase in the plasma total antioxidant status (1.073±0.090mM vs 1.276±0.107mM, P=.028), along with a parallel decrease in malondialdehyde (7.066±1.070μM vs 2.771±0.462μM, P=.005) in the POAG group. The malondialdehyde also decreased in the control group (6.17±1.336 vs. 2.51±0.391, P=.028). The Schirmer test improved (20-30%) and the subjective dry eye signs/symptoms noticeably decreased in the POAG group versus the CG. CONCLUSIONS: Formulations containing antioxidant vitamins, R-alpha lipoic acid and docosahexaenoic acid, administered for 6 consecutive months, counteracted the oxidative stress by further stabilising the morphological/functional parameters of both the ocular surface and the glaucoma, without presenting with adverse effects or intolerances.

Unidad de Investigación Oftalmológica Santiago Grisolía/FISABIO y Grupo de Investigación de la Universidad de Valencia en Oftalmo-biología Celular y Molecular, Valencia, España; Red de Oftalmología de la RETICS: RD16-0008: «Prevención, detección precoz, tratamiento y rehabilitación de las patologías oculares», Instituto de Salud Carlos III, Madrid, España.

Full article

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Classification:

15 Miscellaneous
11.14 Investigational drugs; pharmacological experiments (Part of: 11 Medical treatment)

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