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Abstract #85068 Published in IGR 21-1
CHARGE Syndrome Associated with Angle Closure despite High Myopia: A Case Report with Structural Suggestion
Dote S; Nakakura S; Tanabe H; Terao E; Nagata Y; Tabuchi H; Kiuchi YCase Reports in Ophthalmology 2020; 11: 28-36
CHARGE syndrome is associated with multiple malformations, and the main ocular abnormality is coloboma. We describe an unusual case of a 15-year-old girl with CHARGE syndrome having high intraocular pressure and narrow angle closure despite refractive high myopia (-9.0 dpt) in her left eye. Gonioscopy revealed peripheral anterior synechia (approximately 90°) in the superior quadrant of the left eye. Both eyes exhibited similar axial length (about 22 mm) and corneal curvature (about 8 mm). However, microcornea (9 mm), thicker central cornea and iris induced narrower anterior components in the left eye than in the right eye. Preventing the chance of acute primary angle closure attack, the patient underwent laser iridotomy in the left eye; however, long-term follow-up is needed. Additionally, we developed a hypothesis for the mechanism of unilateral angle closure despite high myopia by investigating the ocular structural parameters in detail.
Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, Japan.
Full articleClassification:
9.4.15 Glaucoma in relation to systemic disease (Part of: 9 Clinical forms of glaucomas > 9.4 Glaucomas associated with other ocular and systemic disorders)
9.3.5 Primary angle closure (Part of: 9 Clinical forms of glaucomas > 9.3 Primary angle closure glaucomas)
8.1 Myopia (Part of: 8 Refractive errors in relation to glaucoma)
