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Abstract #85145 Published in IGR 21-1
Primary Angle Closure Glaucoma-associated Genetic Polymorphisms in Northeast Iran
Yousefian A; Shokoohi-Rad S; Abbaszadegan MR; Rad DM; Zargari S; Milanizadeh S; Morovatdar N; Daneshvar RJournal of ophthalmic & vision research 2020; 15: 45-52
PURPOSE: To evaluate the association of five different polymorphisms from a genome-wide-associated study with susceptibility to glaucoma in the northeast Iranian population. METHODS: Hundred and thirty patients with primary angle closure glaucoma (PACG) and 130 healthy controls were genotyped for the polymorphic regions with the aid of tetra-amplification refractory mutation system-polymerase chain reaction. The association of these variants with the disease susceptibility was measured statistically with the logistic regression method. RESULTS: Hundred and thirty patients with PACG (53 males, 77 females) with a mean age of 64.5 6.2 years and 130 healthy control subjects (51 males, 79 females) with a mean age of 64.0 5.7 years were selected for evaluation. There was a significant association between rs3816415 ( = 0.005), rs736893 ( 0.001), rs7494379 ( 0.001), and rs1258267 ( = 0.02) with PACG susceptibility. This association could not be shown for rs3739821. CONCLUSION: It was revealed that studied variants in and genes can contribute to the incidence of PACG. Additional studies in other populations are needed to evaluate .
Eye Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Full articleClassification:
3.4.2 Gene studies (Part of: 3 Laboratory methods > 3.4 Molecular genetics)
