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WGA Rescources

Abstract #85196 Published in IGR 21-1

Using BXD mouse strains in vision research: A systems genetics approach

Geisert EE; Williams RW
Molecular Vision 2020; 26: 173-187


We illustrate the growing power of the BXD family of mice (recombinant inbred strains from a cross of C57BL/6J and DBA/2J mice) and companion bioinformatic tools to study complex genome-phenome relations related to glaucoma. Over the past 16 years, our group has integrated powerful murine resources and web-accessible tools to identify networks modulating visual system traits-from photoreceptors to the visual cortex. Recent studies focused on retinal ganglion cells and glaucoma risk factors, including intraocular pressure (IOP), central corneal thickness (CCT), and susceptibility of cellular stress. The BXD family was exploited to define key gene variants and then establish linkage to glaucoma in human cohorts. The power of this experimental approach to precision medicine is highlighted by recent studies that defined cadherin 11 () and a calcium channel () as genes modulating IOP, as a genetic link between CCT and retinal ganglion cell (RGC) death, and as a gene that modulates the susceptibility of RGCs to death after elevated IOP. The role of three of these gene variants in glaucoma is discussed, along with the pathways activated in the disease process.

Department of Ophthalmology, Emory University, 1365B Clifton Road NE Atlanta GA, 30322.


Classification:

5.1 Rodent (Part of: 5 Experimental glaucoma; animal models)



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