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Abstract #8562 Published in IGR 4-3
Effect of different doses of cisatracurium on intraocular pressure in sedated patients
Sator-Katzenschlager SM; Oehmke MJ; Kontaratos M; Wedrich A; Heinze G; Weinstabl CEuropean Journal of Anaesthesiology 2002; 19: 823-828
BACKGROUND AND OBJECTIVE: The aim was to examine the course of intraocular pressure (IOP) after relaxation with different doses of cisatracurium. METHODS: The investigation was carried out as a prospective, randomized double-blind study in a crossover design in 30 postoperative patients with stable hemodynamic and respiratory function (ASA I and II). To exclude any disrupting factors, patients remained intubated and continuously sedated. Twenty patients received an intubation dose (2 x ED95) of cisatracurium (0.1 mg kg-1) compared with atracurium (0.5 mg kg-1). In a second series, ten patients were given an effective dose, ED95 (0.05 mg kg-1), and a repeat dose (0.02 mg kg-1) of cisatracurium. IOP was determined before (T0) as well as one (T1), five (T5), ten (T10), 15 (T15), 20 (T20), and 45 (T45) minutes after bolus administration. RESULTS: IOP decreased after an intubation dose of either cisatracurium or atracurium, and reached a minimum after ten minutes (6.7 ± 2.2 and 7.9 ± 2.1 mmHg, respectively). There was no significant difference between either muscle relaxant (p = 0.27). When lower doses of cisatracurium (0.05 and 0.02 mg kg-1) were applied, IOP also decreased, albeit to a lesser extent and with a delayed onset (8.4 ± 1.9 mmHg after ten minutes, 9.9 ± 3.4 mmHg after 15 minutes). There was no significant difference between dosages (p = 0.44). CONCLUSIONS: Cisatracurium is a useful drug in patients when a decrease of IOP is wanted and where muscle relaxation is necessary and acceptable.
Dr. S.M. Sator-Katzenschlager, University of Vienna, Department of Anaesthesiology and General Intensive Care (B), Austria
Classification:
12.17 Anesthesia (Part of: 12 Surgical treatment)