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Abstract #8573 Published in IGR 5-1
Glaucoma characteristics in 13 families of two to four generations
Agla EK; Balo KP; Agamah AK; Banla M; Koffi Gué BKJournal Français d'Ophtalmologie 2003; 26: 169-174
OBJECTIVE: heredity, one of the risk factors associated with primitive glaucoma, has not yet been studied in Togolese glaucoma patients. In this study, the authors report the characteristics and modes of transmission of the family forms of glaucoma in 13 Togolese families. MATERIAL AND METHODS: From glaucomatous propositus and the presence of blindness unrelated to cataract in the ascendants, the authors carried out a family survey, drew up 13 family trees covering two to four generations in 190 participants. Screening based on tonometry and ophthalmoscopy made it possible, after perimetry, to confirm cases of glaucoma. RESULTS: Glaucomatous blindness was found in 4.2% of the subjects, while 2.1% presented with severe problems with their vision, making a total of 6.3% partially sighted persons due to glaucoma in the group of 190 participants. Glaucoma was confirmed in 57 participants (30%); 24.2% had a bilateral deficit compared to 5.8% with a unilateral perimetric deficit. Eight of the family trees covered four generations, four covered three generations, and two family trees two generations. Analysis of the trees led to the suspicion of dominant autosomal transmission in six families, a recessive form in five families, and sporadic forms in two families. CONCLUSIONS: The presence of hereditary family forms of glaucoma in 11 of 13 families studied indicates a strong suspicion for the presence of a glaucoma gene; this can only be elucidated by means of a further study which would include genetic sequencing.
Dr. E.K. Agla, Service d'Ophtalmologie, CHU Tokoin, BP 57, Lomé, Togo. eagla@hotmail.com
Classification:
1.2 Population genetics (Part of: 1 General aspects)